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*ϣԿʹĵһҩҩҩͼ΢ѹ֮ʹ

ȻЩҩҩֿ򵽣ҽʦɰﲡѡʵ֮ҩʱҩӦϲɳڼʹãԿ񾭽֮ʹ

1965꣬ҩIndomethacineǼ೤Զʹð˾ƥաֹʹƹؽסġ¡ҩЧԡѸ٣һʱεΪ糱Ϊ̴ֹʹֱ1971꣬ӢѧJohn VaneˡVane TheoryDzŽ⿪˰˾ƥڵЩҩյסԭһ̴ֹʹΪǰأﵽסֹʹյá

˺30̴ֹ꣬ʹƳ³£㷺ڹؽ׻ʹƣڶؽ׻ߵʹࡣͳƣ1998꣬ٿһţSAIDsĴ⻹ҩ򵽵ijҩrÿ߸ˣһڷôҩr̨δݣδضã̴ֹʹȫʹ㷺ҩˣ

ôΪʲôθԭϸѪ⣬ܺϳǰءǰбࡢֹѪδζĤĹܩr棬ҲԷӦաǿʹĽʡؽ׵ʹʣġ

ͳķ̴ֹʹףͬʱãЧסֹʹգҲõĹܣθθסθѪѪļٵȸáδ֪

ҽһֱŬͼҪǰصġõġ롸ġֿܷr1992John Vane˹ؼǰغϳɵĽأ酶Cyclooxygenase COXܡԭһеĻ酶COX1ϸԶɣϳǰءõġ֣ǿѪѪСθճĤrڶл酶COX2֯յǿԷӦʹգǰءġ֡

߼ϣȥߴݼCOX2COX1ҽĿҩ뷨½棬ǰѡCOX2ķ̴ֹʹдҩȺ󿪷רһֻCOX2ҩ↑˷̴ֹʹҩ¼Ԫؽҩθв˴Ľ츣˲ˡӹΰJohn Vane1998Ӧҽѧ̨ҲӮŵҽѧ




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